7 Symptoms of Peyronie’s Disease, 2 Phases, Causes, Treatment & Cure

Issues to find out about Peyronie’s illness

Peyronie’s illness is a situation wherein scar tissue develops contained in the penis.

  • Peyronie’s illness is the event of scar tissue contained in the penis that ends in an irregular curvature of the penis.
  • The precise reason behind Peyronie’s illness will not be recognized; nonetheless, analysis has steered these brokers as potential causes of plaque or scar formation within the penile shaft.
    • Vitamin E deficiency
    • Beta-blocking medicine
    • Elevation in serotonin ranges
    • Genetic causes
    • Trauma to the penis
  • A number of the signs of Peyronie’s illness embrace:
  • Peyronie’s illness is identified by bodily examination of the penis that exhibits irregular curvature and plaque/scar formation that could be palpated.
  • There is no such thing as a treatment for Peyronie’s illness; nonetheless, signs might be handled with nutritional vitamins, dietary supplements, and different medicines.
  • Issues of the illness embrace ache with intercourse, incapability to have intercourse, erectile dysfunction, despair, and everlasting irregular angulation of the penis.
  • The prognosis of Peyronie’s illness varies from good to poor, relying on the person’s response to remedies.

Peyronie’s Illness Signs & Indicators

Indicators and signs of Peyronie’s illness embrace an

What’s Peyronie’s illness?

Peyronie’s illness (additionally termed Peyronie illness) is the event of scar tissue contained in the penis that causes the penis to develop irregular curvature (contracture) within the scarred space. The illness could happen in about 1% to eight% of males, most steadily in males aged about 40 to 70 years previous. The illness additionally could happen extra steadily in males who develop:

Often, the illness can happen in youthful males.

What are the signs of Peyronie’s illness?

The signs of Peyronie’s illness normally are a mixture of a number of signs as follows:

  • Uncommon angulation of the penile shaft (both when flaccid or erect or each)
  • Ache throughout erections and/or throughout intercourse
  • Scarring or plaque palpated on the irregular bend or angle of the penis
  • An indentation of the penis shaft on the website of the plaque or scarring
  • Erectile dysfunction
  • Nervousness/stress
  • Lack of ability to have intercourse


Peyronie’s Illness (Curvature of the Penis)
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What causes Peyronie’s illness?

The precise reason behind Peyronie’s illness will not be recognized. Nevertheless, no matter may cause plaque or scar formation within the penile shaft is a possible causal candidate.

  • Researchers have steered a number of potential brokers corresponding to vitamin E deficiency, beta-blocking medicines, elevations in serotonin, and genetic causes.
  • Some researchers assume that minor vascular traumas to the penis (throughout intercourse, athletic, or train endeavors) that happen repeatedly over time could result in scar formation.
  • None of those potential brokers or processes is confirmed to be the trigger thus far.

What are the 2 phases of Peyronie’s illness?

There are, normally, two phases of Peyronie’s illness.

  1. The acute section lasts about 18 to 24 months and normally has the very best ache element.
  2. The power section (which begins about 18 to 24 months after the primary signs) normally has much less ache however on this stage, the plaque or scarring is extra refractory to therapy (see beneath) and should start to develop massive calcium deposits (calcified plaque or scarring).

What procedures and checks diagnose Peyronie’s illness?

The affected person’s historical past of ache with erections and/or intercourse and the bodily examination of the penis that exhibits irregular angulation of the penile shaft or the presence of plaque or scarring felt or palpated within the penis is normally the idea for prognosis.

  • Urologists are specialists who normally diagnose and deal with this illness.
  • There are not any definitive blood checks for this illness, though a human cell antigen, HLA-B7 has been related to the illness.
  • Typically, no further checks are vital, however ultrasound methods, when accompanied by an injection of the drug into the penis (intercavernous injection) may help present the physician the place and the way intensive is the scarring and support the physician in figuring out remedies.

What’s the therapy for Peyronie’s illness?

A number of sorts of remedies are designed to cut back the signs of Peyronie’s illness.

Drugs, house cures, nutritional vitamins, and dietary supplements

In December, 2013, the FDA permitted collagenase clostridium histolyticum (Xiaflex) to deal with people with Peyronie’s illness. Every therapy cycle consists of two Xiaflex injections into the plaque within the penis to interrupt up the collagen that causes the curvature deformity. Remedies include a most 4 injections.

Oral remedy with vitamin E, colchicine, PABA, tamoxifen, and different medicines have been tried with restricted success in some sufferers. Normally these within the acute section of the illness responded finest.

Within the early levels of the illness, erectile dysfunction (ED) could also be handled with such medicine as sildenafil (Viagra), vardenafil (Levitra), and tadalafil (Cialis, Adcirca).

Injection remedy makes use of mixtures of medication talked about above and provides prostaglandin E1 or different medicine corresponding to betamethasone alone or with hyaluronidase; PABA has been reported to cut back the penile plaque dimension.

Different medicine have additionally been used with various diploma of success. Verapamil (Calan, Verelan, Verelan PM, Isoptin, Isoptin SR, Covera-HS [a medication usually used for high blood pressure treatment]) seems to disrupt the manufacturing of a protein concerned within the formation of Peyronie’s illness lesions.

One other methodology is iontophoresis (additionally termed electromotive administration or EMDA) the place verapamil and different medicine are utilized to the penile pores and skin and pushed by the pores and skin with a low electrical present.


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Shockwave remedy

Shockwave remedy (achieved with a lithotripter system like these used to interrupt up kidney stones) has been used on plaque or scarring that’s calcified. Different mechanical gadgets, together with vacuum-based machines and low-dose radiotherapy, have been tried. Though some successes are seen with these strategies, the perfect outcomes are in acute section sufferers.

There are ongoing research with completely different medicine (for instance, interferons, and collagenase) and surgical methods.

Surgical procedure

Surgical remedy is completed on some sufferers. These surgical sufferers normally have to fulfill standards which will differ from surgeon to surgeon. Typically, surgical remedy is completed when different strategies have failed or the affected person is within the power stage of the illness and erectile dysfunction is a part of the affected person’s signs.

Surgical remedy could contain

  • incision or chopping the scarred tissue,
  • scar tissue elimination,
  • scar tissue elimination with auto-grafting, or
  • synthetic graft materials.
  • As well as, implanted gadgets (penile implants) that enable the affected person to maintain an erection are additionally utilized in some people.

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Can workouts assist Peyronie’s illness?

Some people counsel stretching and/or milking the penis are workouts that may assist cut back the penile curvature that happens within the illness. Sufferers ought to focus on these methods with their physician (urologist) earlier than utilizing these strategies.

What are the problems of Peyronie’s illness?

The problems of the illness are primarily the signs of:

  • Ache
  • Painful intercourse
  • Lack of ability to have intercourse because of ache or erectile dysfunction
  • Everlasting angulation of the penis

As well as, surgical problems could embrace:

  • Discount in penis size
  • Infections
  • Lack of any erectile capabilities

Melancholy and stress can turn into vital problems.

What’s the prognosis for Peyronie’s illness? Can it’s cured?

The prognosis (consequence) of this illness is variable, from good to poor, relying on the response to therapy and the affected person’s emotional response to the signs and coverings. There is no such thing as a therapy that may treatment Peyronie’s illness, however signs might be diminished.

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Medically Reviewed on 7/7/2022


“Peyronie Illness.” Medscape. Up to date July 25, 2018.

Brant, WO, MD, et al. “Peyronie’s illness: Analysis and medical administration.” UpToDate. Up to date: Dec. 18, 2018.

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