He’s being acknowledged for main the trouble to sequence the primary human most cancers genomes, from sufferers with acute myeloid leukemia (AML). These research helped to create a basis for the Most cancers Genome Atlas, elucidated many beforehand unknown drivers of AML, and outlined the function of clonal heterogeneity in AML development and relapse.
Ley’s analysis focuses on understanding the molecular underpinnings of AML, together with the acquired mutations and altered gene expression patterns answerable for the illness’s initiation, development and relapse. A present focus of his work includes learning AML initiating occasions and the way they reprogram hematopoietic stem and progenitor cells to make them more healthy for transformation, with the purpose of resulting in new approaches for treating myeloid malignancies.
Ley shares the award with Robert Montgomery, MD, a scientific investigator from the Medical Faculty of Wisconsin, who’s being acknowledged for his contributions to the understanding of hemophilia.
Ley additionally just lately was honored by France’s Fondation ARC for most cancers analysis with the extremely prestigious Léopold Griffuel Prize for primary analysis. Fondation ARC acknowledges worldwide most cancers researchers who “suppose exterior the field and persevere to translate analysis outcomes into advantages for sufferers.”
He shared the fiftieth annual Griffuel Prize with Pasi A. Jänne, MD, PhD, of the Dana-Farber Most cancers Institute, who research the genetic modifications that underlie the event of lung most cancers. Each physician-scientists are featured on this video that highlights their strategy to science and the importance of their discoveries.