Vitamin D Overdose: How Much Is Too Much?

Newest Prevention & Wellness Information

WEDNESDAY, July 6, 2022

Vitamin D dietary supplements are sometimes touted for his or her well being advantages, from boosting the immune system to guarding towards most cancers. However as one British man came upon, it is doable to get an excessive amount of of a great factor.

Vitamin D overdosing — clinically referred to as hypervitaminosis D — is linked to a variety of doubtless critical well being points, say medical doctors reporting a current case research a couple of man hospitalized for the situation.

“Globally, there’s a rising pattern of hypervitaminosis D, a scientific situation characterised by elevated serum vitamin D3 ranges,” the authors wrote. Ladies, kids and surgical sufferers are more than likely to be affected.

Dr. Alamin Alkundi, of East Kent Hospitals College NHS Basis Belief in England, was the lead creator of the case research. It was revealed July 6 in BMJ Case Experiences.

It reported on a middle-aged man who was hospitalized after complaining of recurrent vomiting, nausea, belly ache, leg cramps, ringing within the ear, dry mouth, diarrhea and weight reduction.

The signs, which had been occurring for 3 months, started a month after he began a vitamin routine advisable by a dietary therapist. The routine included greater than 20 over-the-counter every day dietary supplements.

The affected person had beforehand had a lot of well being points, together with tuberculosis, an inside ear tumor, a buildup of fluid within the mind, bacterial meningitis and continual sinusitis, in response to the case research.

As soon as his signs started, he stopped taking the dietary supplements, which included 50,000 mg of every day vitamin D, however his signs persevered. The advisable every day requirement for vitamin D is about 600 mg for adults.

Blood checks discovered that the person had very excessive ranges of calcium, barely raised ranges of magnesium and a vitamin D degree about seven instances above that required for sufficiency.

Scans and X-rays checked for most cancers however discovered nothing irregular. The person had acute kidney damage.

Throughout eight days within the hospital, he was given intravenous fluids to flush out his system and handled with bisphosphonates. These medicine can strengthen bones or decrease extreme blood ranges of calcium.

Testing two months after he was discharged discovered regular calcium ranges, however nonetheless an abnormally excessive vitamin D degree.

“Given its gradual turnover [half-life of approximately two months], throughout which vitamin D toxicity develops, signs can final for a number of weeks,” the authors mentioned in a journal information launch.

Advisable vitamin D ranges may be obtained from publicity to daylight, dietary supplements and sure meals, together with salmon, sardines, tuna, beef liver, and fortified milk, cereal and orange juice.

The authors mentioned individuals could not notice that it is doable to overdose on vitamin D, or the potential penalties of doing so.


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“This case report additional highlights the potential toxicity of dietary supplements which might be largely thought-about secure till taken in unsafe quantities or in unsafe combos,” they concluded.

The signs that hypervitaminosis D causes are principally resulting from extra calcium within the blood. They’ll embody drowsiness, confusion, apathy, psychosis, despair, stupor, coma, anorexia, belly ache, vomiting, constipation, peptic ulcers, pancreatitis, hypertension, irregular coronary heart rhythm, kidney abnormalities and kidney failure. It might additionally result in an inflammatory eye illness, joint stiffness and listening to loss, the researchers mentioned.

Extra data

The U.S. Nationwide Institutes of Well being has extra on vitamin D.

SOURCE: BMJ, information launch, July 6, 2022

By Cara Murez HealthDay Reporter


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